The present study aims to explore the effect of positive religious affirmations as an intervention in combination with Positive Group Psychotherapy, among subjects with depression. In a pre-post quasi experimental design, 14 depressed individuals were approached from Karachi, Pakistan through purposive sampling technique. Randomly, seven individuals were assigned to Group A and seven were assigned to Group B. Group A received 7 therapeutic group sessions consisting of religious affirmations along with positive psychotherapy. Group B received 7 therapeutic group sessions including purely positive psychotherapy interventions. Comparison of depression levels was made between pre intervention and post intervention. Siddiqui Shah Depression Scale was used for the measurement of level of depression. Results of the study indicated that positive religious affirmations in combination with positive group psychotherapy lead to a significant decline in depression level when compared pre-test and post-test, but post test results indicated insignificant level of difference between depression level of Group A and Group B. Current study has important implications for clinical and psychotherapeutic settings.