The present study is aimed at exploring the difference between work as a stressor and work as a social resource between working middle aged married men and women in Karachi. Given the importance to middle aged working married men and women it was hypothesized that there would be a significant difference of work as a life stressor and social resource between working middle aged married men and women. A total of 150 participants including 75 working married men and 75 working married women from the middle socioeconomic status involved in various occupations from Karachi were included in the sample for the research. Their age range was 35 to 55 years and their education was at least at the graduation level. The Life Stressors and Social Resources Inventory - Adult Form (LISRES-A) by Moos and Moos (1994) was administered on an individual basis. The results provided partially significant support for the hypothesis. Work as a life stressor was found to be significantly different (t=3.207, p<.00) for middle aged working married men and women. However work as a social resource was not found to be significantly different (t=0.914, p>.05) for middle aged working married men and women.