The aim of this study was to investigate the gender difference in executive functions of secondary school students in Karachi. It was hypothesized that “Male students will score higher on the variable of Executive Functions as compared to female students”. Following a comparative research design a sample of 100 (50 male and 50 female) students with grade level of 7 and 8 were randomly selected from various private English medium schools of Karachi-Pakistan. The age range of participants was from 12 to 14 years (mean age: 12.50; SD = .92). After establishing the rapport and written informed consent, the demographic form was filled in and the Behavior Rating Inventory of Executive Function -BRIEF was administered. Statistical analysis showed that there is a significant difference on the variable of executive functions (p<.05) where boys scored higher on global, as well as sub domains of executive functions as compared to girls of secondary school students. Limitations and recommendations are also suggested.